Ways of dying: multiple pathways to apoptosis

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Ways of dying: multiple pathways to apoptosis.

In order to eliminate cells that are redundant, damaged, or infected, metazoan organisms have evolved the cell suicide mechanism termed apoptosis (Kerr et al. 1972). This genetic program is vital for normal development, for maintenance of tissue homeostasis, and for an effective immune system. Not surprisingly therefore, its disturbance is implicated in numerous pathological conditions, ranging...

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Apoptosis or programmed cell death is a gene regulated phenomenon which is important in both physiological and pathological conditions. It is characterized by distinct morphological features including chromatin condensation, cell and nuclear shrinkage, membrane blebbing and oligonucleosomal DNA fragmentation. Although, two major apoptotic pathways including 1) the death receptor (extrinsic) and...

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apoptosis: from signalling pathways to therapeutic tools

apoptosis or programmed cell death is a gene regulated phenomenon which is important in both physiological and pathological conditions. it is characterized by distinct morphological features including chromatin condensation, cell and nuclear shrinkage, membrane blebbing and oligonucleosomal dna fragmentation. although, two major apoptotic pathways including 1) the death receptor (extrinsic) and...

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PML Degradation: Multiple Ways to Eliminate PML

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ژورنال

عنوان ژورنال: Genes & Development

سال: 2003

ISSN: 0890-9369

DOI: 10.1101/gad.1126903